A re-formulation of generalized linear mixed models to fit family data in genetic association studies

The generalized linear mixed model (GLMM) is a useful tool for modeling genetic correlation among family data in genetic association studies. However, when dealing with families of varied sizes and diverse genetic relatedness, the GLMM has a special correlation structure which often makes it difficu...

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Bibliographic Details
Published in:Front Genet
Main Authors: Wang, Tao, He, Peng, Ahn, Kwang Woo, Wang, Xujing, Ghosh, Soumitra, Laud, Purushottam
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379931/
https://ncbi.nlm.nih.gov/pubmed/25873936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00120
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