The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation

BACKGROUND: Neuroinflammation is a hallmark that leads to selective neuronal loss and/or dysfunction in neurodegenerative disorders. Microglia-derived lysosomal cathepsins are increasingly recognized as important inflammatory mediators to trigger signaling pathways that aggravate neuroinflammation....

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Fan, Kai, Li, Daobo, Zhang, Yanli, Han, Chao, Liang, Junjie, Hou, Changyi, Xiao, Hongliang, Ikenaka, Kazuhiro, Ma, Jianmei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379721/
https://ncbi.nlm.nih.gov/pubmed/25889123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0268-x
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