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Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding.

We have made mutations in the predicted sixth transmembrane segment of a rat B2 bradykinin receptor and analyzed the variant proteins by expressing them in COS-1 cells. Two amino acid substitutions reduced the affinity of the receptor for bradykinin (Phe261-->Val by 1600-fold; Thr265-->Ala by...

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Detalhes bibliográficos
Main Authors: Nardone, J, Hogan, P G
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC43796/
https://ncbi.nlm.nih.gov/pubmed/8183923
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