Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding.
We have made mutations in the predicted sixth transmembrane segment of a rat B2 bradykinin receptor and analyzed the variant proteins by expressing them in COS-1 cells. Two amino acid substitutions reduced the affinity of the receptor for bradykinin (Phe261-->Val by 1600-fold; Thr265-->Ala by 700-fo...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183923/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4417 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|