Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study

Alpha-fetoprotein (AFP) is a diagnostic marker for hepatocellular carcinoma (HCC). A direct relationship between poor prognosis and the concentration of serum AFP has been observed. Telomerase, an enzyme that stabilizes the telomere length, is expressed by 90% of HCC. The aim of this study was to in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Tahtouh, Roula, Azzi, Anne-Sophie, Alaaeddine, Nada, Chamat, Soulaima, Bouharoun-Tayoun, Hasnaa, Wardi, Layal, Raad, Issam, Sarkis, Riad, Antoun, Najibe Abou, Hilal, George
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379025/
https://ncbi.nlm.nih.gov/pubmed/25822740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119512
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