Protection against Mycobacterium tuberculosis Infection Offered by a New Multistage Subunit Vaccine Correlates with Increased Number of IFN-γ(+)IL-2(+) CD4(+) and IFN-γ(+) CD8(+) T Cells

Protein subunit vaccines present a compelling new area of research for control of tuberculosis (TB). Based on the interaction between Mycobacterium tuberculosis and its host, five stage-specific antigens of M. tuberculosis that participate in TB pathogenesis—Rv1813, Rv2660c, Ag85B, Rv2623, and HspX—...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Xiaochun, Zhang, Jingyan, Liang, Jinping, Zhang, Ying, Teng, Xindong, Yuan, Xuefeng, Fan, Xionglin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378938/
https://ncbi.nlm.nih.gov/pubmed/25822536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122560
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