Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a by-product of castor oil. RT has two subunits, a ribotoxic A chain (RTA) and galactose-binding B...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Roy, Chad J., Brey, Robert N., Mantis, Nicholas J., Mapes, Kelly, Pop, Iliodora V., Pop, Laurentiu M., Ruback, Stephen, Killeen, Stephanie Z., Doyle-Meyers, Lara, Vinet-Oliphant, Heather S., Didier, Peter J., Vitetta, Ellen S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378443/
https://ncbi.nlm.nih.gov/pubmed/25775591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502585112
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