Computational protein design enables a novel one-carbon assimilation pathway

We describe a computationally designed enzyme, formolase (FLS), which catalyzes the carboligation of three one-carbon formaldehyde molecules into one three-carbon dihydroxyacetone molecule. The existence of FLS enables the design of a new carbon fixation pathway, the formolase pathway, consisting of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Siegel, Justin B., Smith, Amanda Lee, Poust, Sean, Wargacki, Adam J., Bar-Even, Arren, Louw, Catherine, Shen, Betty W., Eiben, Christopher B., Tran, Huu M., Noor, Elad, Gallaher, Jasmine L., Bale, Jacob, Yoshikuni, Yasuo, Gelb, Michael H., Keasling, Jay D., Stoddard, Barry L., Lidstrom, Mary E., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378393/
https://ncbi.nlm.nih.gov/pubmed/25775555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500545112
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