LKB1 reduces ROS-mediated cell damage via activation of p38

Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutated in Peutz-Jeghers syndrome and in a variety of sporadic cancers. Herein, we demonstrate that LKB1 controls the levels of intracellular reactive oxygen species (ROS) and protects the genome from oxida...

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Udgivet i:Oncogene
Main Authors: Xu, Hua-Guo, Zhai, Ying-Xian, Chen, Jianfeng, Lu, Yibing, Wang, Jian-Wei, Quan, Cheng-Shi, Zhao, Rui-Xun, Xiao, Xuxian, He, Qiongqiong, Werle, Kaitlin D., Kim, Hyung-Gyoon, Lopez, Richard, Cui, Rutao, Liang, Jiyong, Li, Yu-Lin, Xu, Zhi-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377312/
https://ncbi.nlm.nih.gov/pubmed/25263448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.315
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