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Mitochondrial Replacement Therapy in Reproductive Medicine

Mitochondrial dysfunction is implicated in disease and in age-related infertility. Mitochondrial replacement therapies (MRT) in oocytes or zygotes such as pronuclear (PNT), spindle (ST) or polar body (PBT) transfer could prevent second generation transmission of mitochondrial DNA (mtDNA) defects. PN...

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Detalhes bibliográficos
Publicado no:Trends Mol Med
Main Authors: Wolf, Don P., Mitalipov, Nargiz, Mitalipov, Shoukhrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377089/
https://ncbi.nlm.nih.gov/pubmed/25573721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2014.12.001
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