Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases: the CHARISMA randomized multicenter clinical trial

BACKGROUND: Efforts to improve the outcome of liver surgery by combining curative resection with chemotherapy have failed to demonstrate definite overall survival benefit. This may partly be due to the fact that these studies often involve strict inclusion criteria. Consequently, patients with a hig...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Ayez, Ninos, van der Stok, Eric P, de Wilt, Hans, Radema, Sandra A, van Hillegersberg, Richard, Roumen, Rudi M, Vreugdenhil, Gerard, Tanis, Pieter J, Punt, Cornelis J, Dejong, Cornelis H, Jansen, Rob L, Verheul, Henk M, de Jong, Koert P, Hospers, Geke A, Klaase, Joost M, Legdeur, Marie-Cecile, van Meerten, Esther, Eskens, Ferry A, van der Meer, Nelly, van der Holt, Bruno, Verhoef, Cornelis, Grünhagen, Dirk J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377036/
https://ncbi.nlm.nih.gov/pubmed/25884448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1199-8
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