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A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles

We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of...

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Pubblicato in:PLoS One
Autori principali: Schappacher-Tilp, Gudrun, Leonard, Timothy, Desch, Gertrud, Herzog, Walter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376863/
https://ncbi.nlm.nih.gov/pubmed/25816319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117634
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