Targeted Germline Modifications in Rats using CRISPR/Cas9 and Spermatogonial Stem Cells

Organisms with targeted genomic modifications are efficiently produced by gene editing in embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline editing in rats, we used CRISPR/Cas9 to catalyze targeted genomic mutations in rat spermatogonial stem cell cultures. CRISPR/C...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Chapman, Karen M., Medrano, Gerardo A., Jaichander, Priscilla, Chaudhary, Jaideep, Waits, Alexandra E., Nobrega, Marcelo A., Hotaling, James M., Ober, Carole, Hamra, F. Kent
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376630/
https://ncbi.nlm.nih.gov/pubmed/25772367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.040
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