Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression

Bile acids have been shown to be important hormones during the feed/fast cycle, allowing the liver to coordinately regulate nutrient metabolism. How they accomplish this has not been fully elucidated. Conjugated bile acids have been shown to activate both the ERK1/2 and AKT signaling pathways via S1...

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Udgivet i:Hepatology
Main Authors: Nagahashi, Masayuki, Takabe, Kazuaki, Liu, Runping, Peng, Kesong, Wang, Xiang, Wang, Yun, Hait, Nitai C., Wang, Xuan, Allegood, Jeremy C., Yamada, Akimitsu, Aoyagi, Tomoyoshi, Liang, Jie, Pandak, William M., Spiegel, Sarah, Hylemon, Phillip B., Zhou, Huiping
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376566/
https://ncbi.nlm.nih.gov/pubmed/25363242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27592
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