Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception

Testosterone (T), alone or in combination with progestin, provides a promising approach to hormonal male contraception. Its principle relies on enhanced negative feedback of exogenous T to suppress gonadotropins, thereby blocking the testicular T production needed for spermatogenesis, while simultan...

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Vydáno v:FASEB J
Hlavní autoři: Oduwole, Olayiwola O., Vydra, Natalia, Wood, Nicholas E. M., Samanta, Luna, Owen, Laura, Keevil, Brian, Donaldson, Mandy, Naresh, Kikkeri, Huhtaniemi, Ilpo T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2014
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376501/
https://ncbi.nlm.nih.gov/pubmed/24599970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-249219
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