Inositol-1,4,5-trisphosphate induced Ca(2+) release and excitation–contraction coupling in atrial myocytes from normal and failing hearts

We studied excitation–contraction coupling (ECC) and inositol-1,4,5-triphosphate (IP(3))-dependent Ca(2+) release in normal and heart failure (HF) rabbit atrial cells. Left ventricular HF was induced by combined volume and pressure overload. In HF atrial myocytes diastolic [Ca(2+)](i) was increased,...

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Bibliographic Details
Published in:J Physiol
Main Authors: Hohendanner, Felix, Walther, Stefanie, Maxwell, Joshua T, Kettlewell, Sarah, Awad, Sawsan, Smith, Godfrey L, Lonchyna, Vassyl A, Blatter, Lothar A
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376424/
https://ncbi.nlm.nih.gov/pubmed/25416623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.283226
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