Targeted nuclear antisense RNA mimics natural antisense-induced degradation of polyoma virus early RNA.
We describe a general antisense strategy to inhibit target gene expression. The substitution of a cis-acting ribozyme for a polyadenylylation signal in an antisense expression vector results in the nuclear retention of RNAs and the efficient degradation of their targets. We demonstrate the utility o...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4258 |
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