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Correlation between Activation of PI3K/AKT/mTOR Pathway and Prognosis of Breast Cancer in Chinese Women

BACKGROUND: Abnormal activation of PI3K/AKT/mTOR (PAM) pathway, caused by PIK3CA mutation, KRAS mutation, PTEN loss, or AKT1 mutation, is one of the most frequent signaling abnormalities in breast carcinoma. However, distribution and frequencies of mutations in PAM pathway are unclear in breast canc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Deng, Ling, Chen, Jie, Zhong, Xiao Rong, Luo, Ting, Wang, Yan Ping, Huang, Hui Fen, Yin, Li-Juan, Qiu, Yan, Bu, Hong, Lv, Qing, Zheng, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376391/
https://ncbi.nlm.nih.gov/pubmed/25816324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120511
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