FRESCo: finding regions of excess synonymous constraint in diverse viruses

BACKGROUND: The increasing availability of sequence data for many viruses provides power to detect regions under unusual evolutionary constraint at a high resolution. One approach leverages the synonymous substitution rate as a signature to pinpoint genic regions encoding overlapping or embedded fun...

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Bibliografiska uppgifter
I publikationen:Genome Biol
Huvudupphovsmän: Sealfon, Rachel S, Lin, Michael F, Jungreis, Irwin, Wolf, Maxim Y, Kellis, Manolis, Sabeti, Pardis C
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2015
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Method
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376164/
https://ncbi.nlm.nih.gov/pubmed/25853568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0603-7
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