Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition

Previously, we described the safety and therapeutic potential of neurospheres (NSs) derived from a human induced pluripotent stem cell (iPSC) clone, 201B7, in a spinal cord injury (SCI) mouse model. However, several safety issues concerning iPSC-based cell therapy remain unresolved. Here, we investi...

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Publicado en:Stem Cell Reports
Autores principales: Nori, Satoshi, Okada, Yohei, Nishimura, Soraya, Sasaki, Takashi, Itakura, Go, Kobayashi, Yoshiomi, Renault-Mihara, Francois, Shimizu, Atsushi, Koya, Ikuko, Yoshida, Rei, Kudoh, Jun, Koike, Masato, Uchiyama, Yasuo, Ikeda, Eiji, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375796/
https://ncbi.nlm.nih.gov/pubmed/25684226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.01.006
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