Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface

The epidermal growth factor receptor (EGFR) is a well characterized receptor-tyrosine kinase that functions in development and serves a vital role in many human cancers. Understanding EGFR regulatory mechanisms, and hence approaches for clinical intervention, has focused on ligand-receptor interacti...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Dong, Aiwen, Wodziak, Dariusz, Lowe, Anson W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375459/
https://ncbi.nlm.nih.gov/pubmed/25666625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623207
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