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Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked o...

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Publicado en:PLoS Genet
Main Authors: Ye, Liang, Morse, Leslie R., Zhang, Li, Sasaki, Hajime, Mills, Jason C., Odgren, Paul R., Sibbel, Greg, Stanley, James R. L., Wong, Gee, Zamarioli, Ariane, Battaglino, Ricardo A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374855/
https://ncbi.nlm.nih.gov/pubmed/25811986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005057
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