Abnormal Accumulation of Desmin in Gastrocnemius Myofibers of Patients with Peripheral Artery Disease: Associations with Altered Myofiber Morphology and Density, Mitochondrial Dysfunction and Impaired Limb Function

Patients with peripheral artery disease (PAD) develop a myopathy in their ischemic lower extremities, which is characterized by myofiber degeneration, mitochondrial dysfunction and impaired limb function. Desmin, a protein of the cytoskeleton, is central to maintenance of the structure, shape and fu...

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Veröffentlicht in:J Histochem Cytochem
Hauptverfasser: Koutakis, Panagiotis, Miserlis, Dimitrios, Myers, Sara A., Kim, Julian Kyung-Soo, Zhu, Zhen, Papoutsi, Evlampia, Swanson, Stanley A., Haynatzki, Gleb, Ha, Duy M., Carpenter, Lauren A., McComb, Rodney D., Johanning, Jason M., Casale, George P., Pipinos, Iraklis I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374059/
https://ncbi.nlm.nih.gov/pubmed/25575565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155415569348
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