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Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells
Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to the culture medium to sustain continued cell growth resulting in the accumulation of lactate to high levels. In such...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373774/ https://ncbi.nlm.nih.gov/pubmed/25806512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121561 |
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