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Recurring use of a gene regulatory network to orchestrate innate and adaptive cell fates in the immune system
The transcription factor PU.1 functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage fate. We now demonstrate that Gfi-1 reciprocally promotes B cell fate choice at the expense of myeloid progeny. Gfi-1(−/−) MPPs are unable to con...
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| Pubblicato in: | Immunity |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373467/ https://ncbi.nlm.nih.gov/pubmed/19818654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.011 |
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