Loading...
Recurring use of a gene regulatory network to orchestrate innate and adaptive cell fates in the immune system
The transcription factor PU.1 functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage fate. We now demonstrate that Gfi-1 reciprocally promotes B cell fate choice at the expense of myeloid progeny. Gfi-1(−/−) MPPs are unable to con...
Na minha lista:
| Udgivet i: | Immunity |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373467/ https://ncbi.nlm.nih.gov/pubmed/19818654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.011 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|