New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway

G protein-coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases , which differ considerably in their cellular distribution and activation mechanisms. Once produced, cyclic AMP may...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Godinho, Rosely O., Duarte, Thiago, Pacini, Enio S. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373373/
https://ncbi.nlm.nih.gov/pubmed/25859216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00058
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