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Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50

Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues in human brain from those who either age with...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Aboud, Orwa, Parcon, Paul A., DeWall, K. Mark, Liu, Ling, Mrak, Robert E., Griffin, W. Sue T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373372/
https://ncbi.nlm.nih.gov/pubmed/25859183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00103
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