Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

BACKGROUND: KCNJ2/Kir2.1, a member of the classical inwardly rectifying potassium channel family, is commonly expressed in a wide range of tissues and cell types. Previous studies indicated that Kir2.1 may be associated with SCLC multidrug resistance (MDR). However, whether Kir2.1 can regulate MDR a...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Liu, Huanxin, Huang, Jie, Peng, Juan, Wu, Xiaoxia, Zhang, Yan, Zhu, Weiliang, Guo, Linlang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373128/
https://ncbi.nlm.nih.gov/pubmed/25880778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0298-0
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