Methylmercury Impairs Canonical Dopamine Metabolism in Rat Undifferentiated Pheochromocytoma (PC12) Cells by Indirect Inhibition of Aldehyde Dehydrogenase

The environmental neurotoxicant methylmercury (MeHg) disrupts dopamine (DA) neurochemical homeostasis by stimulating DA synthesis and release. Evidence also suggests that DA metabolism is independently impaired. The present investigation was designed to characterize the DA metabolomic profile induce...

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Publicat a:Toxicol Sci
Autors principals: Tiernan, Chelsea T., Edwin, Ethan A., Hawong, Hae-Young, Ríos-Cabanillas, Mónica, Goudreau, John L., Atchison, William D., Lookingland, Keith J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Methylmercury and Dopamine Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372664/
https://ncbi.nlm.nih.gov/pubmed/25601988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv001
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