IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment

The inhibition of NF-κB by genetic deletion or pharmacological inhibition of IKK2 significantly reduces laser-induced choroid neovascularization (CNV). To achieve a sustained and controlled intraocular release of a selective and potent IKK2 inhibitor, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gaddipati, Subhash, Lu, Qingxian, Kasetti, Ramesh Babu, Miller, M. Clarke, Lu, Qingjun, Trent, John O., Kaplan, Henry J., Li, Qiutang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372421/
https://ncbi.nlm.nih.gov/pubmed/25803615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121185
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