A Novel Triple Repeat Mutant Tau Transgenic Model That Mimics Aspects of Pick’s Disease and Fronto-Temporal Tauopathies

Tauopathies are a group of disorders leading to cognitive and behavioral impairment in the aging population. While four-repeat (4R) Tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and Alzheimer’s disease, three-repeat (3R) Tau is the most abundant splice, in Pick&#...

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Vydáno v:PLoS One
Hlavní autoři: Rockenstein, Edward, Overk, Cassia R., Ubhi, Kiren, Mante, Michael, Patrick, Christina, Adame, Anthony, Bisquert, Alejandro, Trejo-Morales, Margarita, Spencer, Brian, Masliah, Eliezer
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372415/
https://ncbi.nlm.nih.gov/pubmed/25803611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121570
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