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The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764–838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. Consequently, EPAC1 is mainly localised to the nuclear pore complex in HEK293T cells where it becomes activated following stimulation w...

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Foilsithe in:Cell Signal
Main Authors: Parnell, Euan, Smith, Brian O., Yarwood, Stephen J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier Science Ltd 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372255/
https://ncbi.nlm.nih.gov/pubmed/25683912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.02.009
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