Endocannabinoids are conserved inhibitors of the Hedgehog pathway

Hedgehog ligands control tissue development and homeostasis by alleviating repression of Smoothened, a seven-pass transmembrane protein. The Hedgehog receptor, Patched, is thought to regulate the availability of small lipophilic Smoothened repressors whose identity is unknown. Lipoproteins contain l...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Khaliullina, Helena, Bilgin, Mesut, Sampaio, Julio L., Shevchenko, Andrej, Eaton, Suzanne
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371992/
https://ncbi.nlm.nih.gov/pubmed/25733905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416463112
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