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Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
Polymerases have a structurally highly conserved negatively charged amino acid motif that is strictly required for Mg(2+) cation-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids. Based on these characteristics, a nucleoside monophosphonate scaffold, α-carboxy nucleoside pho...
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Veröffentlicht in: | Proc Natl Acad Sci U S A |
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Hauptverfasser: | , , , , , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
National Academy of Sciences
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371953/ https://ncbi.nlm.nih.gov/pubmed/25733891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420233112 |
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