Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Polymerases have a structurally highly conserved negatively charged amino acid motif that is strictly required for Mg(2+) cation-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids. Based on these characteristics, a nucleoside monophosphonate scaffold, α-carboxy nucleoside pho...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Balzarini, Jan, Das, Kalyan, Bernatchez, Jean A., Martinez, Sergio E., Ngure, Marianne, Keane, Sarah, Ford, Alan, Maguire, Nuala, Mullins, Niki, John, Jubi, Kim, Youngju, Dehaen, Wim, Vande Voorde, Johan, Liekens, Sandra, Naesens, Lieve, Götte, Matthias, Maguire, Anita R., Arnold, Eddy
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371953/
https://ncbi.nlm.nih.gov/pubmed/25733891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420233112
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker