Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Polymerases have a structurally highly conserved negatively charged amino acid motif that is strictly required for Mg(2+) cation-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids. Based on these characteristics, a nucleoside monophosphonate scaffold, α-carboxy nucleoside pho...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Balzarini, Jan, Das, Kalyan, Bernatchez, Jean A., Martinez, Sergio E., Ngure, Marianne, Keane, Sarah, Ford, Alan, Maguire, Nuala, Mullins, Niki, John, Jubi, Kim, Youngju, Dehaen, Wim, Vande Voorde, Johan, Liekens, Sandra, Naesens, Lieve, Götte, Matthias, Maguire, Anita R., Arnold, Eddy
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371953/
https://ncbi.nlm.nih.gov/pubmed/25733891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420233112
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