Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Polymerases have a structurally highly conserved negatively charged amino acid motif that is strictly required for Mg(2+) cation-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids. Based on these characteristics, a nucleoside monophosphonate scaffold, α-carboxy nucleoside pho...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Balzarini, Jan, Das, Kalyan, Bernatchez, Jean A., Martinez, Sergio E., Ngure, Marianne, Keane, Sarah, Ford, Alan, Maguire, Nuala, Mullins, Niki, John, Jubi, Kim, Youngju, Dehaen, Wim, Vande Voorde, Johan, Liekens, Sandra, Naesens, Lieve, Götte, Matthias, Maguire, Anita R., Arnold, Eddy
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371953/
https://ncbi.nlm.nih.gov/pubmed/25733891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420233112
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