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Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y(1/6) chimeric receptors

P2Y receptors are G protein-coupled receptors stimulated by extracellular nucleotides. Both the P2Y(1) and the P2Y(6) receptors are preferentially activated by nucleoside 5′-diphosphates, but favor different base moieties. In the case of the P2Y(1) receptor the preferred base is adenine, while the P...

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Publicat a:Biochem Pharmacol
Autors principals: Hoffmann, Carsten, Soltysiak, Kelly, West, Patrick L., Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371599/
https://ncbi.nlm.nih.gov/pubmed/15476678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2004.07.014
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