Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have b...

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Publicat a:Mem Inst Oswaldo Cruz
Autors principals: Souza, Thiago Moreno Lopes e, Fintelman-Rodrigues, Natalia, Resende, Paola Cristina, Mesquita, Milene, Gregianini, Tatiana Schaffer, Bozza, Fernando A, Pecego, Ana Carla, Fernandes, Sandra Bianchini, Cury, Ana Luisa Furtado, Riediger, Irina Nastassja, Siqueira, Marilda M
Format: Artigo
Idioma:Inglês
Publicat: Instituto Oswaldo Cruz, Ministério da Saúde 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371223/
https://ncbi.nlm.nih.gov/pubmed/25742269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760140330
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