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Rational Manipulation of mRNA Folding Free Energy Allows Rheostat Control of Pneumolysin Production by Streptococcus pneumoniae

The contribution of specific factors to bacterial virulence is generally investigated through creation of genetic “knockouts” that are then compared to wild-type strains or complemented mutants. This paradigm is useful to understand the effect of presence vs. absence of a specific gene product but c...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Amaral, Fábio E., Parker, Dane, Randis, Tara M., Kulkarni, Ritwij, Prince, Alice S., Shirasu-Hiza, Mimi M., Ratner, Adam J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370707/
https://ncbi.nlm.nih.gov/pubmed/25798590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119823
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