Near Infra-Red Photoimmunotherapy with Anti-CEA-IR700 Results in Extensive Tumor Lysis and a Significant Decrease in Tumor Burden in Orthotopic Mouse Models of Pancreatic Cancer

Photoimmunotherapy (PIT) of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maawy, Ali A., Hiroshima, Yukihiko, Zhang, Yong, Heim, Roger, Makings, Lew, Garcia-Guzman, Miguel, Luiken, George A., Kobayashi, Hisataka, Hoffman, Robert M., Bouvet, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370703/
https://ncbi.nlm.nih.gov/pubmed/25799218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121989
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