The Human Cytomegalovirus UL133-138 Gene Locus Attenuates the Lytic Viral Cycle in Fibroblasts

The genomes of HCMV clinical strains (e.g. FIX, TR, PH, etc) contain a 15 kb region that encodes 20 putative ORFs. The region, termed ULb’, is lost after serial passage of virus in human foreskin fibroblast (HFF) cell culture. Compared to clinical strains, laboratory strains replicate faster and to...

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Bibliographic Details
Published in:PLoS One
Main Authors: Dutta, Nirmal, Lashmit, Philip, Yuan, Jinxiang, Meier, Jeffery, Stinski, Mark F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370700/
https://ncbi.nlm.nih.gov/pubmed/25799165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120946
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