Selective Dicer Suppression in the Kidney Alters GSK3β/β-Catenin Pathways Promoting a Glomerulocystic Disease

Dicer is a crucial enzyme for the maturation of miRNAs. Mutations in the Dicer gene are highly associated with Pleuro Pulmonary Blastoma-Family Dysplasia Syndrome (PPB-FDS, OMIM 601200), recently proposed to be renamed Dicer syndrome. Aside from the pulmonary phenotype (blastoma), renal nephroma and...

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Publicat a:PLoS One
Autors principals: Iervolino, Anna, Trepiccione, Francesco, Petrillo, Federica, Spagnuolo, Manuela, Scarfò, Marzia, Frezzetti, Daniela, De Vita, Gabriella, De Felice, Mario, Capasso, Giovambattista
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370407/
https://ncbi.nlm.nih.gov/pubmed/25799508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119142
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