2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay. Since 2ME causes mitotic perturbations, we examined its interactions with tubulin. In our standard 1.0 M glutamate system (plus 1.0 mM MgCl2 at 37 degrees C), superstoichi...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	D'Amato, R J, Lin, C M, Flynn, E, Folkman, J, Hamel, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43703/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8171020/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.9.3964
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