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A hinge migration mechanism unlocks the evolution of green-to-red photoconversion in GFP-like proteins
In proteins, functional divergence involves mutations that modify structure and dynamics. Here, we provide experimental evidence for an evolutionary mechanism driven solely by long-range dynamic motions without significant backbone adjustments, catalytic group rearrangements, or changes in subunit a...
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| Udgivet i: | Structure |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4370283/ https://ncbi.nlm.nih.gov/pubmed/25565105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.11.011 |
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