The Compromise of Macrophage Functions by Hyperoxia Is Attenuated by Ethacrynic Acid via Inhibition of NF-κB–Mediated Release of High-Mobility Group Box-1

The prolonged exposure to hyperoxia can compromise macrophage functions and contribute to the development of ventilator-associated pneumonia. High levels of extracellular high-mobility group box-1 (HMGB1) in the airways of mice exposed to hyperoxia can directly cause macrophage dysfunction. Hence, i...

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Bibliografiska uppgifter
I publikationen:Am J Respir Cell Mol Biol
Huvudupphovsmän: Wang, Mao, Gorasiya, Samir, Antoine, Daniel J., Sitapara, Ravikumar A, Wu, Wenjun, Sharma, Lokesh, Yang, Huan, Ashby, Charles R., Vasudevan, Divya, Zur, Michelle, Thomas, Douglas D., Mantell, Lin L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Thoracic Society 2015
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370245/
https://ncbi.nlm.nih.gov/pubmed/24992505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0544OC
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