Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits

Ample evidence supports genetic and functional heterogeneity in primary tumors, but it remains unclear whether circulating tumor cells (CTCs) also exhibit the same hierarchical organization. We examined the functional diversity of viable, single CTCs using an array of subnanoliter wells (nanowells)....

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Detalhes bibliográficos
Publicado no:Integr Biol (Camb)
Main Authors: Yao, Xiaosai, Choudhury, Atish D., Yamanaka, Yvonne J., Adalsteinsson, Viktor A., Gierahn, Todd M., Williamson, Christina A., Lamb, Carla R., Taplin, Mary-Ellen, Nakabayashi, Mari, Chabot, Matthew S., Li, Tiantian, Lee, Gwo-Shu M., Boehm, Jesse S., Kantoff, Philip W., Hahn, William C., Wittrup, K. Dane, Love, J. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369918/
https://ncbi.nlm.nih.gov/pubmed/24522233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ib40264a
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