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Evidence for Two Pathways of Iodothyronine 5′-Deiodination in Rat Pituitary That Differ in Kinetics, Propylthiouracil Sensitivity, and Response to Hypothyroidism

We have studied 5′-deiodination of thyroxine (T(4)) and 3,3′,5′-triiodothyronine (rT(3)) in rat pituitary tissue in vitro, with respect to substrate specificity, reaction kinetics, effects of 6-n-propyl-2-thiouracil (PTU), and the time course of effects of thyroid hormone depletion and repletion. Re...

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Bibliografische gegevens
Hoofdauteurs: Visser, Theo J., Kaplan, Michael M., Leonard, Jack L., Larsen, P. Reed
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1983
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC436957/
https://ncbi.nlm.nih.gov/pubmed/6833498
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