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Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral mediated enkephalin overproduction in male and female rats

BACKGROUND: Clinical studies have tested the use of an engineered herpes virus to treat pain. We hypothesized that subcutaneous injections of an engineered herpes virus that expresses enkephalin would attenuate orofacial nociception and hypersensitivity in male and female rats by a central mechanism...

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Detalhes bibliográficos
Publicado no:BMC Neurol
Main Authors: Kramer, Phillip R, Umorin, Mikhail, Bellinger, Larry L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369359/
https://ncbi.nlm.nih.gov/pubmed/25885338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-015-0285-5
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