Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats

BACKGROUND: Infectious Leptospira colonize the kidneys of reservoir (e.g. rats) and accidental hosts such as humans. The renal response to persistent leptospiral colonization, as measured by urinary protein biosignatures, has not been systematically studied. Urinary exosomes--bioactive membrane-boun...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: RamachandraRao, Satish P., Matthias, Michael A., Mondrogon, Chanthel-Kokoy, Aghania, Eamon, Park, Cathleen, Kong, Casey, Ishaya, Michelle, Madrigal, Assael, Horng, Jennifer, Khoshaba, Roni, Bounkhoun, Anousone, Basilico, Fabrizio, De Palma, Antonella, Agresta, Anna Maria, Awdishu, Linda, Naviaux, Robert K., Vinetz, Joseph M., Mauri, Pierluigi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368819/
https://ncbi.nlm.nih.gov/pubmed/25793258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003640
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