Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

BACKGROUND: Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat-shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases. Cancer-associated fibroblasts (CAFs) are also thought to play a role...

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Pubblicato in:PLoS One
Autori principali: Schweiger, Thomas, Nikolowsky, Christoph, Starlinger, Patrick, Traxler, Denise, Zimmermann, Matthias, Birner, Peter, Hegedüs, Balazs, Dome, Balazs, Bergmann, Michael, Mildner, Michael, Klepetko, Walter, Hoetzenecker, Konrad, Ankersmit, Hendrik Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368667/
https://ncbi.nlm.nih.gov/pubmed/25793600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120724
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