NEDDylation Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients. For many non-viral malignancies, therapeutically targeting the ubiquitin proteasome s...

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Vydáno v:PLoS Pathog
Hlavní autoři: Hughes, David J., Wood, Jennifer J., Jackson, Brian R., Baquero-Pérez, Belinda, Whitehouse, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368050/
https://ncbi.nlm.nih.gov/pubmed/25794275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004771
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