Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles

Apolipoprotein M (apoM), a plasma sphingosine 1-phosphate (S1P) carrier, associates with plasma HDL via its uncleaved signal peptide. Hepatocyte-specific apoM overexpression in mice stimulates formation of both larger nascent HDL in hepatocytes and larger mature apoM/S1P-enriched HDL particles in pl...

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Udgivet i:J Biol Chem
Main Authors: Liu, Mingxia, Allegood, Jeremy, Zhu, Xuewei, Seo, Jeongmin, Gebre, Abraham K., Boudyguina, Elena, Cheng, Dongmei, Chuang, Chia-Chi, Shelness, Gregory S., Spiegel, Sarah, Parks, John S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367285/
https://ncbi.nlm.nih.gov/pubmed/25627684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631101
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